abstract：:About 2% of the general population and up to 6% of children suffer from food allergy. Cow's milk is charged with a important role in infancy after weaning, since conventional formula are based on its procession. IgE-mediated and Non-IgE- mediated allergic reactions, which are different in manifestation and pathogenesi...

journal_title：Klinische Padiatrie

authors： Kirchlechner V,Dehlink E,Szepfalusi Z

更新日期：2007-07-01 00:00:00

abstract：:Since 1962, desferrioxamine (deferoxamine, DFO) has been utilized for the treatment of secondary hemosiderosis. For about 30 years, DFO therapy has been performed as nightly continuous subcutaneous infusion. About 20 years ago, the first oral iron chelator (deferiprone, DFP) was presented. Concerns about potential sid...

journal_title：Klinische Padiatrie

authors： Cario H,Janka-Schaub G,Janssen G,Jarisch A,Strauss G,Kohne E

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Surveys in USA and UK have shown inconsistencies between practice of sweat testing and guidelines of the National Committee for Clinical Laboratory Standards (NCCLS), which could increase the risk of false-positive and -negative results. To determine the current practice of sweat testing in German cystic fib...

journal_title：Klinische Padiatrie

authors： Naehrlich L

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Modern neonatal and pediatric intensive care includes a sophisticated pharmacotherapy with numerous drugs, mainly administered intravenously. Often, despite the use of multi-lumen central venous lines, more peripheral venous accesses are required. To reduce the necessity of numerous venous lines on one hand ...

journal_title：Klinische Padiatrie

authors： Höpner JH,Schulte A,Thiessen J,Knuf M,Huth RG

更新日期：2007-01-01 00:00:00

abstract：:The biologic behaviour of teratomas depends on various interdependent clinical and epidemiologic variables such as the age at diagnosis, sex, tumor site, histology which all correlate to different cytogenetic and molecular biologic aberrations. Thus, testicular teratomas of infancy are generally benign. Accordingly, p...

journal_title：Klinische Padiatrie

authors： Harms D,Zahn S,Göbel U,Schneider DT

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Reimbursement of inpatient treatment by daily constant charges is replaced by diagnosis- and procedure-related group system (G-DRG) in German acute care hospitals excerpt for psychiatry since 2004. Re-designs of G-DRG system were undertaken in 2005 and 2006. Parallel to implementation requirement- and resour...

journal_title：Klinische Padiatrie

authors： Christaras A,Schaper J,Strelow H,Laws HJ,Göbel U

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Flank swelling and pseudotumors of the kidney are unusual manifestations of obstructive uropathies in small children. Our case illustrates typical problems and briefly reviews management options. CASE REPORT:A 5-week-old boy presented with a large, palpable urinoma due to posterior urethral valves. Sonograp...

journal_title：Klinische Padiatrie

authors： von Schnakenburg C,Dorn A,Jacobi C,Fisch D,Pohl M,Frankenschmidt A

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Intracellular antibodies (intrabodies) have been used for the generation of phenotypic knockouts in vivo by surface depletion of extracellular or transmembrane proteins. Intrabodies present an alternative to methods of gene inactivation that target genomic DNA or m-RNA, such as RNA interference. Several stud...

journal_title：Klinische Padiatrie

authors： Jendreyko N,Rader C,Barbas CF 3rd,Gaedicke G

更新日期：2006-05-01 00:00:00

abstract：:Mucoid impaction and plastic bronchitis are relatively rare disorders affecting patients of any age. Here we report the case of mucoid impaction developing in a four-year-old child as a complication of pneumonic infection treated four weeks prior. p.a. chest X-ray and fiberoptic bronchoscopy showed atelectasis and the...

journal_title：Klinische Padiatrie

authors： Kamin W,Klär-Hlawatsch B,Truebel H

更新日期：2006-03-01 00:00:00

abstract：:Wegener's granulomatosis is together with Churg-Strauss syndrome and microscopic polyangiitis a very rare cause of hemoptysis in childhood. We report on a 14 years old girl who developed arthralgia, purpura, glomerulonephritis and a diffuse alveolar haemorrhage with hemoptysis after a short time period of unspecific s...

journal_title：Klinische Padiatrie

authors： Heckmann M,Weber K,Reineck P,Schüler D,Geidel C,Steiss JO

更新日期：2006-01-01 00:00:00

abstract：:The rapid institution of empirical broad-spectrum antibiotics has become the gold standard of treatment for febrile neutropenic children undergoing therapy for cancer. With this approach, morbidity and mortality have dropped significantly but have not been eliminated altogether. In recent randomized studies evaluating...

journal_title：Klinische Padiatrie

authors： Laws HJ,Ammann RA,Lehrnbecher T

更新日期：2005-11-01 00:00:00

abstract：:Infectious complications are a major cause of morbidity and mortality in pediatric and adult patients undergoing hematopoietic stem cell transplantation. The incidence and the severity code of infections depend on the function of the host's immune system. This function is strongly correlated to the application of immu...

journal_title：Klinische Padiatrie

authors： Schuster FR,Laws HJ

更新日期：2005-11-01 00:00:00

abstract：UNLABELLED:We present updated results of stem cell transplantation with highly purified stem cells from haploidentical parental donors and infection with human adenovirus (HAdV) post stem cell transplantation (SCT). Survival post SCT is primarily determined by relapse, infections and far less by GvHD or other transplan...

journal_title：Klinische Padiatrie

authors： Feuchtinger T,Richard C,Pfeiffer M,Neuhäuser F,Lücke J,Handgretinger R,Greil J,Bader P,Klingebiel T,Schlegel PG,Jahn G,Niethammer D,Lang P

更新日期：2005-11-01 00:00:00

abstract：:We report on a phenotypically male newborn with 45,X/46,X,dic(Y)-mosaicism. Right-sided inguinal hernia was surgically corrected. Histological examination of the tissue revealed an ambiguously differentiated gonad on this side. The clinical, cytogenetic, and histological results are described and the prognosis and cli...

journal_title：Klinische Padiatrie

authors： Bittmann S,Wieczorek D,Stallmach T,Ulus H

更新日期：2005-09-01 00:00:00

abstract：QUESTIONS:Psychosocial variables like stress or a high achievement motivation are discussed as a possible contributory factor to an attack in migraine. The aim of our study was to examine, whether children with migraine may be at risk for impaired achievement motivation. PATIENTS/METHODS:37 children with migraine and ...

journal_title：Klinische Padiatrie

authors： Haverkamp F,Hönscheid A,Rünger M,Krois A,Harbauer A

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Late effects become progressively more important for the evaluation of therapeutic success in paediatric oncology. Thus, in 1998, the Late Effects Surveillance System (LESS) started to register and assess multicentrally, prospectively and longitudinally late effects of treatment for the group of Ewing's, sof...

journal_title：Klinische Padiatrie

authors： Langer T,Stöhr W,Paulides M,Kremers A,Dörr HG,Göbel U,Beck JD

更新日期：2005-05-01 00:00:00

abstract：:This report describes the case of a 10 days old newborn of a diabetic mother with gestosis, who developed erythema and swelling of the right cheek. A diagnosis of acute suppurative parotitis due to S. aureus was made. Following this case report the most important facts of epidemiology, pathogenesis, clinical manifesta...

journal_title：Klinische Padiatrie

authors： Möckel A,Nissler K,Wilhelm T,Handrick W

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Peripheral schwannomas and pilomatrixoma are rare clinical features in childhood. The concomitant presence of these tumors in childhood are not described yet. PATIENTS:We describe the first case of a concomitant peripheral benign schwannoma and pilomatrixoma located at the head in a 10-year-old female patie...

journal_title：Klinische Padiatrie

authors： Bittmann S,Ulus H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Essential Thrombocythemia (ET) is an acquired myeloproliferative disorder (MPD) characterized by excessive production of platelets. The disorder is usually affecting adults and is rarely diagnosed in children. PATIENTS AND METHODS:In this retrospective study we describe 12 children aged 5-16 years in whom E...

journal_title：Klinische Padiatrie

authors： Kratz CP,Abd El-Monheim A,Manke EM,Rister M,Rogge T,Niemeyer CM

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Although considered of high prognostic impact, knowledge on the long-term outcome after neonatal parenchymatous brain lesions (PBL) is limited. PATIENTS:29 children with either unilateral (n = 19) or bilateral (n = 10) hemorrhagic/ischemic PBL. METHODS:The patients were reinvestigated at 9 9/12 +/- 3 4/12 ...

journal_title：Klinische Padiatrie

authors： Häusler M,Merz U,Van Tuil C,Ramaekers VT

更新日期：2004-07-01 00:00:00

abstract：:Polycythemia vera - the most frequent form of a primary erythrocytosis in adult patients - represents an extremely rare disease in pediatric and juvenile patients as do congenital primary and secondary erythrocytoses. Frequently, in patients with these diseases clinical problems do not occur before adulthood. Systemat...

journal_title：Klinische Padiatrie

authors： Cario H,Schwarz K,Debatin KM,Kohne E

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Epidemiology and resistance patterns of bacterial pathogens in pediatric UTI show large interregional variability and rates of bacterial resistances are changing due to different antibiotic treatment. We intended to evaluate data from northern Germany. PATIENTS AND METHODS:In 100 children (53 female, 47 mal...

journal_title：Klinische Padiatrie

authors： Pape L,Gunzer F,Ziesing S,Pape A,Offner G,Ehrich JH

更新日期：2004-03-01 00:00:00

abstract：:We studied the influence of preload augmentation on Doppler-derived left ventricular diastolic function parameters in infants with a birth weight <1500 g. In 44 neonates with a closed duct and 29 neonates with an open ductus arteriosus a complete echocardiographic study including Doppler investigations of the mitral i...

journal_title：Klinische Padiatrie

authors： Schmitz L,Stiller B,Koehne P,Koch H,Lange PE

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The aim of most of the trials of the Competence Network Malignant Lymphoma is to optimize the standard treatment of lymphoma using only registered drugs in the case of medicinal therapies (quality assurance protocols). In contrast to regulatory trials, special regulations for quality assurance protocols are ...

journal_title：Klinische Padiatrie

authors： Pfistner B,Mehl C,Klöss M,Löffler M,Herrmann-Frank A,Diehl V

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Hypoallergenic infant formulas (HAF) were developed for atopy prevention in infants with high risk of atopy if these cannot be breastfed. HAF mount an antigen-specific immune response in infants. The aim of the study was to analyse the immune response in infants fed with a new infant formula based on a whey ...

journal_title：Klinische Padiatrie

authors： Nentwich I,Pazdírková A,Koberská I,Pokojská E,Szépfalusi Z,Lokaj J

更新日期：2003-09-01 00:00:00

abstract：:In a retrospective study we evaluated clinical features and diagnostic impact of sonography, white blood cell count, C-reactive protein as well as bacterial etiology of children treated surgically for bacterial cervical lymphadenitis. We report on 38 children at the age between 2.5 months and 14 years who were admitte...

journal_title：Klinische Padiatrie

authors： Tröbs RB,Gräfe G,Müller P,Handrick W

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Up to now, reliable data has not been available on the actual costs of treating oncological patients. However, such data material is urgently required in view of the institution of the health service reform with the concomitant introduction of the G-DRG remuneration system. PATIENTS:The medical services and...

journal_title：Klinische Padiatrie

authors： Stäbler W,Wagner B

更新日期：2003-05-01 00:00:00

abstract：:Hypotension is diagnosed in a high percentage of very low birth weight infants, particularly in the first 24 hours after birth and the resultant clinical approach is to support the blood pressure vigorously. However, the research base is not yet available to give a definite answer to the question, which blood pressure...

journal_title：Klinische Padiatrie

authors： Stopfkuchen H

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Sonographic screening helps to discover pathological findings in asymptomatic patients. In these cases the decision about diagnostic and therapeutic consequences is difficult. CASE REPORT:We describe a girl with a congenital small solitary hepatic cyst with rapidly increasing size after the second year, whi...

journal_title：Klinische Padiatrie

authors： Reichel S,Alzen G,Keller KM,Weitzel D

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:17beta hydroxysteroid dehydrogenase deficiency is a presumable rare cause for a severe virilization disorder in children with 46,XY karyotype due to a defect in the testicular testosterone biosynthesis from androstenedione. PATIENT:We report on a 14 year old child with 46,XY karyotype with a predominantly f...

journal_title：Klinische Padiatrie

authors： Twesten W,Johannisson R,Holterhus PM,Hiort O

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:First-line treatment in AML commonly included high cumulative doses of anthracyclines with an increasing risk of cardiotoxicity. Liposomal daunorubicin (L-DNR) is thought to be less cardiotoxic without impairment of efficacy. METHODS:The AML-BFM REZ 97 study included two reinduction blocks with L-DNR (2 x 6...

journal_title：Klinische Padiatrie

authors： Reinhardt D,Hempel G,Fleischhack G,Schulz A,Boos J,Creutzig U

更新日期：2002-07-01 00:00:00

abstract：:The death of a child after an oncologic disease gives rise to feelings of mourning, loss and anger in family members and often also in oncology team members. All people involved need to find ways of coping with these emotions and thought. Therefore, the oncology team of the Children's Hospital Tuebingen has, for many ...

journal_title：Klinische Padiatrie

authors： Kochendörfer S

更新日期：2002-07-01 00:00:00

abstract：:The lipodystrophy syndromes are rare disorders characterized by the loss of adipose tissue. The loss of fat tissue can have genetic, immune, or infectious/drug-associated causes. With the extent of fat loss metabolic complications, such as insulin resistance, diabetes mellitus, hypertriglyceridemia, and fatty liver in...

journal_title：Klinische Padiatrie

authors： Fischer-Posovszky P,Debatin KM,Wabitsch M

更新日期：2002-05-01 00:00:00

abstract：:Megestrol acetate (MA) is a synthetic, orally active derivative of the naturally occurring hormone progesterone. MA is increasingly used to correct loss of appetite and improve the nutritional status. We used MA in an adolescent with growth hormone (GH) deficiency due to former irradiation therapy in order to evaluate...

journal_title：Klinische Padiatrie

authors： Schmid I,Stachel DK,Freudenberg S,Schmitt M,Schuster F,Haas RJ

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:In study AML-BFM 87 the relapse rate was lower in patients receiving cranial irradiation (CRT). However, CRT has always been associated with adverse cognitive side effects. Therefore, the impact of CRT on neuropsychological function in children with AML was retrospectively evaluated. PATIENTS:We tested 53 c...

journal_title：Klinische Padiatrie

authors： Reinhardt D,Thiele C,Creutzig U,AML-BFM-Studiengruppe.

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:We wanted improve the nutritional status of patients with cystic fibrosis with enteral feeding via a percutaneous endoscopic gastrostomy (PEG). PATIENTS AND METHODS:In a period of 8 years 11 patients underwent a percutaneous endoscopic gastrostomy (PEG), 4 males and 7 females, in the median 14,9 years of ag...

journal_title：Klinische Padiatrie

authors： Richter T,Meier C,Steppberger K,Knorrek G,Lietz T

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Thyroglossal duct cysts arise from mucus production in an incomplete regressed thyroglossal duct. Often they are only noticed in case of infection or secondary fistulation. The operative management is a Sistrunk procedure. METHOD AND PATIENTS:In a retrospective study we analyse 26 patients aged 0,3 - 10 yea...

journal_title：Klinische Padiatrie

authors： von Bismarck S,Höllwarth ME

更新日期：2001-09-01 00:00:00

abstract：:The control of severe infectious complications by preventive strategies, early diagnosis of infections and empiric broad-spectrum antibiotic therapy contributed to a marked improvement of survival in children with cancer over the last 20 years. This article overviews of the importance of prevention of infectious compl...

journal_title：Klinische Padiatrie

authors： Fleischhack G,Simon A

更新日期：2001-09-01 00:00:00

abstract：:Immunocompromised patients in pediatric hematology-oncology are faced with an increased risk of nosocomial infections (NI). The incidence of NI and the contribution of certain risk factors have not sufficiently been investigated in this population. It is therefore unknown how many NI are preventable through infection ...

journal_title：Klinische Padiatrie

authors： Simon A,Fleischhack G

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:One of the strongest predictive factors for therapy outcome in childhood acute lymphoblastic leukaemia (ALL), treated according to ALL-BFM protocols, is the response to initial prednisone treatment. Prednisone response is characterized by the peripheral leukaemic blast count. The threshold value for the char...

journal_title：Klinische Padiatrie

authors： Lauten M,Stanulla M,Zimmermann M,Welte K,Riehm H,Schrappe M

更新日期：2001-07-01 00:00:00